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Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal. 4 pack USA EPA approved. This item: Advantage II Flea Treatment for Medium Dogs weighing 4.6 kg to 11 kg (10 lbs. Another added advantage of shopping online is that now you can have these delivered to your doorstep. Advantage II 4-Dose Flea and Lice Treatment for Extra Large Dogs, Flea and Lice Treatment for Do… Advantage II topical flea treatment for dogs contains a combination of imidacloprid and pyriproxyfen to kill fleas, flea eggs, flea larvae and lice. Advantage II Flea Treatment for Extra Large Dogs weighing over 25 kg (over 55 lbs.) This flea and tick treatment lasts for 30 days before more is needed. Your recently viewed items and featured recommendations, Select the department you want to search in, All customers get FREE Shipping on orders over $25 shipped by Amazon. 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